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Zestoretic is indicated in the management of mild to moderate hypertension in patients who have been stabilised on the individual components given in the same proportions.
ACE inhibitor and thiazide therapy may impair glucose toleranceDosage adjustment of antidiabetic agentsincluding insulinmay be requiredIn diabetic patients treated with oral antidiabetic agents or insulinglycaemia levels should be closely monitored during the first month of treatment with an ACE inhibitorLatent diabetes mellitus may become manifest during thiazide therapy.
Patients taking cheap zestoretic dosages co-trimoxazoletrimethoprim/sulfamethoxazolemay be at increased risk for hyperkalaemiasee section 4.4
Thiazide diuretics may increase serum calcium levels due to decreased excretionIf calcium supplements or Vitamin D must be prescribedserum calcium levels should be monitored and the dose adjusted accordingly.
ACE inhibitor therapy exposure during the second and third trimesters is known to induce human foetotoxicitydecreased renal functionoligohydramniosskull ossification retardationand neonatal toxicityrenal failurehypotensionhyperkalaemiaSee also section 5.cheap zestoretic dosages safety dataShould exposure to ACE inhibitors have occurred from the second trimester of pregnancyultrasound check of renal function and skull is recommendedInfants whose mothers have taken ACE inhibitors should be closely observed for hypotensionsee also sections 4.3 and 4.4
Call your doctor if you have ongoing vomiting or diarrheaor if you are sweating more cheap zestoretic dosages usualYou can easily become cheap zestoretic dosages while taking this medicineThis can lead to very low blood pressureelectrolyte disordersor kidney failure.
The combination of ACE inhibitors and lithium is cheap zestoretic dosages not recommendedsee section 4.5
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In rare occasionspatients treated with ACE inhibitors during low-density lipoproteinLDLapheresis with dextran cheap zestoretic dosages have shown life threatening anaphylactic reactionsThese symptoms could be avoided by temporary discontinuation of the treatment with ACE cheap zestoretic dosages before each apheresis.
When driving vehicles or operating machines it should be taken into account that occasionally dizziness or tiredness may occur.
Hydrochlorothiazide should not be used for primary hypertension in cheap zestoretic dosages women except in rare situations where no other treatment could be used.
As with other antihypertensiveslisinopril/hydrochlorothiazide combination products may have a mild to moderate influence on the ability to drive and use machinesEspecially at the start of the treatment or when the dose is modifiedand also when used in combination with alcoholbut these affects depend on the individual’s susceptibility
In some patients with heart failure who have normal or low blood pressureadditional lowering of systemic blood pressure may occur with lisinoprilThis effect is cheap zestoretic dosages and is not usually a reason to discontinue treatmentIf hypotension becomes symptomatica reduction of dose or discontinuation of lisinopril-hydrochlorothiazide may be necessary.
Hypokalemia can sensitise or exaggerate the response of the heart to the toxic effects of digitalise.gincreased ventricular irritability
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