Oxycodone is a substrate for cyp3a4 and indinavir is a strong cyp3a4 inhibitor.
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Concomitant use of CRIXIVAN with lovastatin or simvastatin is contraindicated due to an increased risk of myopathy including rhabdomyolysisCaution should be exercised if CRIXIVAN is used concurrently with atorvastatin or rosuvastatinTitrate the atorvastatin and rosuvastatin doses cheap crixivan/indinavir and use the lowest necessary dose with CRIXIVANSee PRECAUTIONSDRUG INTERACTIONS
Cheap crixivan/indinavir is not known whether CRIXIVAN is dialyzable by peritoneal or hemodialysis.
Table 9Established and Other Potentially Significant Drug InteractionsAlteration in Dose or Regimen May Be Recommended Based on Cheap crixivan/indinavir Interaction Studies or Predicted InteractionSee also CLINICAL PHARMACOLOGY for magnitude of interactionWARNINGS and DOSAGE AND ADMINISTRATION
3Skinhair and nails Some indinavir users have reported thinner hair or temporary loss of hairDry skindry or cracked lipsand ingrown toenails have also been reported by indinavir usersThese symptoms are sometimes referred to as ectodermal dysplasiaFor more information about options to help manage this please see CATIE’s A Practical Guide to HIV Drug Side Effects
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Of courseif you have persistent diarrhea or vomitingyou should contact your doctor.
It is important for you to keep a written list of all of the prescription and nonprescriptionover-the-countermedicines you are takingas well as any products such as vitaminsmineralsor other dietary supplementsYou should bring this list with you each time you visit a doctor or if you are admitted to a hospitalIt is also important information to carry with you in case of emergencies.
Patients with hemophiliaThere have been reports of spontaneous bleeding in patients with hemophilia A and B treated with protease inhibitorsIn some patientsadditional factor VIII was requiredIn many of the reported casestreatment with protease inhibitors was continued or restartedA causal relationship between protease inhibitor therapy and these episodes has not been establishedSee ADVERSE REACTIONSPost-Marketing Experience
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In addition to adequate hydrationmedical management in patients who experience nephrolithiasis/urolithiasis may include temporary interruptione.g1 to 3 daysor discontinuation of therapy.
Indinavir belongs to a group or class of drugs cheap crixivan/indinavir protease inhibitorsIndinavir interferes with an enzyme called proteasewhich is used by Cheap crixivan/indinavir-infected cells to make new virusesSince indinavir inhibitsor reduces the activity of this enzymethis drug causes HIV-infected cells to produce fewer viruses.
CRIXIVAN is contraindicated in patients with clinically significant hypersensitivity to any of its components.
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